- Title
- Diffusion entropy vs. multiscale and renyi entropy to detect progression of autonomic neuropathy
- Creator
- Jelinek, Herbert F.; Tuladhar, Rohisha; Culbreth, Garland; Bohara, Gyanendra; Cornforth, David; West, Bruce J.; Grigolini, Paolo
- Relation
- Frontiers in Physiology Vol. 11, no. 607324
- Publisher Link
- http://dx.doi.org/10.3389/fphys.2020.607324
- Publisher
- Frontiers Media
- Resource Type
- journal article
- Date
- 2021
- Description
- We review the literature to argue the importance of the occurrence of crucial events in the dynamics of physiological processes. Crucial events are interpreted as short time intervals of turbulence, and the time distance between two consecutive crucial events is a waiting time distribution density with an inverse power law (IPL) index μ, with μ < 3 generating non-stationary behavior. The non-stationary condition is characterized by two regimes of the IPL index: (a) perennial non-stationarity, with 1 < μ < 2 and (b) slow evolution toward the stationary regime, with 2 < μ < 3. Human heartbeats and brain dynamics belong to the latter regime, with healthy physiological processes tending to be closer to the border with the perennial non-stationary regime with μ = 2. The complexity of cognitive tasks is associated with the mental effort required to address a difficult task, which leads to an increase of μ with increasing task difficulty. On this basis we explore the conjecture that disease evolution leads the IPL index μ moving from the healthy condition μ = 2 toward the border with Gaussian statistics with μ = 3, as the disease progresses. Examining heart rate time series of patients affected by diabetes-induced autonomic neuropathy of varying severity, we find that the progression of cardiac autonomic neuropathy (CAN) indeed shifts μ from the border with perennial variability, μ = 2, to the border with Gaussian statistics, μ = 3 and provides a novel, sensitive index for assessing disease progression. We find that at the Gaussian border, the dynamical complexity of crucial events is replaced by Gaussian fluctuation with long-time memory.
- Subject
- crucial events; complexity; diffusion entropy; multiscale entropy; Rényi entropy; autonomic neuropathy
- Identifier
- http://hdl.handle.net/1959.13/1421173
- Identifier
- uon:37692
- Identifier
- ISSN:1664-042X
- Rights
- © 2021 Jelinek, Tuladhar, Culbreth, Bohara, Cornforth, West and Grigolini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
- Language
- eng
- Full Text
- Reviewed
- Hits: 11773
- Visitors: 11959
- Downloads: 210
| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT02 | Publisher version (open access) | 678 KB | Adobe Acrobat PDF | View Details Download |